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This methylation profile is presently acquired with the MBL stage3 and continues to be reasonably secure with time. Having said that, some CLL have intratumor variability in specific locations, which can alter the expression of many genes and aid tumor evolution.71 Of Notice, this variability is bigger in U-CLL than in M-CLL and is linked to expanding variety of subclones.seven,71
translocations or amplifications in addition to the genomic alterations presently existing in the initial CLL, but lack the prevalent mutations observed in Most important DLBCL indicating they might correspond to another biological classification.
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